Publications

18 Jan Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2

Posted at 10:56h in Publications by Jess Nithianantharajah

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https://onlinelibrary.wiley.com/doi/10.1111/gbb.12723 Abstract The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell‐adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling and plasticity underlying behaviour. Increasingly, mutations in genes that encode postsynaptic proteins belonging to the PSD‐95...

11 Jan Assessing generalization in 5-HTT KO rats

Posted at 12:26h in Publications by Chao Guo

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Abstract Understanding the common dimension of mental disorders (such as anxiety, depression, and drug addiction) might contribute to the construction of biological frameworks (Research Domain Criteria, RDoC) for novel ways of treatment. One common dimension at the behavioral level observed across these disorders is a generalization....

05 Jan Touchscreen Iowa Gambling Task and LSD

Posted at 13:14h in Publications by Lauri Elsilä

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Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task Link to the full manuscript: https://doi.org/10.3389/fphar.2020.602770 Abstract While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects...

01 Dec Using Touchscreen Equipped Operant Chambers to Study Comparative Cognition. Benefits, Limitations, and Advice.

Posted at 13:14h in Publications by Benjamin Seitz

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Abstract: Operant chambers are small enclosures used to test animal behavior and cognition. While traditionally reliant on simple technologies for presenting stimuli (e.g., lights and sounds) and recording responses made to basic manipulanda (e.g., levers and buttons), an increasing number of researchers are beginning to use...

26 Nov Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Posted at 17:05h in Publications by Ornela Kljakic

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Abstract Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit formation is modulated by striatal cholinergic interneurons. These interneurons express...

25 Nov Maternal immune activation targeted to a window of parvalbumin interneuron development improves spatial working memory: Implications for autism

Posted at 10:47h in Publications by Rachel Hill

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Manuscript link: https://authors.elsevier.com/a/1b~dA_KDvPMW1g We found that exposure to maternal immune activation during a window of parvalbumin interneuron development caused in adulthood increased performance on the TUNL spatial working memory task. This increase in performance occurred only at separations 3 and 2, not separation 1 and 0. This...

17 Nov A molecular insight into the dissociable regulation of associative learning and motivation by the synaptic protein neuroligin-1

Posted at 17:34h in Publications by Jess Nithianantharajah

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Abstract Background: In a changing environment, a challenge for the brain is to flexibly guide adaptive behavior towards survival. Complex behavior and the underlying neural computations emerge from the structural components of the brain across many levels: circuits, cells, and ultimately the signaling complex of proteins...

17 Nov MicroRNA-210 Regulates Dendritic Morphology and Behavioral Flexibility in Mice

Posted at 17:25h in Publications by Jess Nithianantharajah

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Abstract: MicroRNAs are known to be critical regulators of neuronal plasticity. The highly-conserved, hypoxia-regulated microRNA-210 (miR-210) has been shown to be associated with long term memory in invertebrates and dysregulated in neurodevelopmental and neurodegenerative disease models. However, the role of miR-210 in mammalian neuronal function and...

16 Nov Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer’s Disease

Posted at 11:41h in Publications by Hendrik Nieraad

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Abstract Background: Hyperhomocysteinemia is considered a possible contributor to the complex pathology of Alzheimer’s disease (AD). For years, researchers in this field have discussed the apparent detrimental effects of the endogenous amino acid homocysteine in the brain. In this study, the roles of hyperhomocysteinemia driven by...

13 Nov Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task

Posted at 15:51h in Publications by Lin Kooi Ong

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Abstract For many chronic stroke survivors, persisting cognitive dysfunction leads to significantly reduced quality of life. Translation of promising therapeutic strategies aimed at improving cognitive function is hampered by existing, disparate cognitive assessments in animals and humans. In this study, we assessed post-stroke cognitive function using...