Publications

PUBLISHED JOURNAL ARTICLE: Genes, Brain, and Behavior - https://doi.org/10.1111/gbb.12755. ABSTRACT: While there is a strong focus on the negative consequences of maternal immune activation (MIA) on developing brains, very little attention is directed towards potential advantages of early life challenges. In this study we utilized a...

https://link.springer.com/article/10.1007/s10072-020-04910-8 Rationale The activation of the glucagon-like peptide-1 receptor (GLP-1R) has been purported to have antidepressant-like and cognitive-enhancing effects. Many people suffering from major depressive disorder (MDD) also experience deficits in cognition. While currently approved antidepressant pharmacotherapies can alleviate the mood symptoms in some patients, they do...

Kevin J. Norman Hiroyuki Koike Sarah E. McCraney Yury Garkun Julia Bateh Elisa N. Falk Susanna Im Keaven Caro Michael P. Demars Hirofumi Morishita Neuropsychopharmacology Reports, 06 May 2021 https://doi.org/10.1002/npr2.12176 https://onlinelibrary.wiley.com/doi/full/10.1002/npr2.12176 Abstract Aim: Attention is a goal‐directed cognitive process that facilitates the detection of task‐relevant sensory stimuli from dynamic...

Translating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are...

Abstract Cognitive impairment is a common and disruptive outcome for stroke survivors, which is recognized to be notoriously difficult to treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function and limits secondary neuronal loss in the thalamus after experimental stroke. There is...

Abstract There is emerging evidence suggesting that a cortical stroke can cause delayed and remote hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to investigate motor and cognitive outcomes after experimental stroke, and their association with secondary neurodegenerative processes. Specifically, we used a...

Falk EN, Norman KJ, Garkun Y, Demars MP, Im S, Taccheri G, Short J, Caro K, McCraney SE, Cho C, Smith MR, Lin HM, Koike H, Bateh J, Maccario P, Waltrip L, Janis M, Morishita H. Science Advances 2021 Mar 5;7(10):eabe1527. doi: 10.1126/sciadv.abe1527. https://advances.sciencemag.org/content/7/10/eabe1527 Abstract: Cognitive function depends on...

Koike, H., Demars, M.P., Short, J.A., Nabel, E.M., Akbarian, S., Baxter, M.G, Morishita, H. Neuropsychopharmacology 2016. Mar, 41 (4) 1014-23, doi: 10.1038/npp.2015.229. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748426/ Abstract: Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC)...

X
Skip to toolbar