Publications

Abstract In the striatum, cholinergic interneurons (CINs) have the ability to release both acetylcholine and glutamate, due to the expression of the vesicular acetylcholine transporter (VAChT) and the vesicular glutamate transporter 3 (VGLUT3). However, the relationship these neurotransmitters have in the regulation of behavior is not...

Norman KJ, Bateh J, Maccario P, Cho C, Caro K, Nishioka T, Koike H, Morishita H Front Neurosci. 2022 Jan 11 doi: 10.3389/fnins.2021.775256 https://www.frontiersin.org/articles/10.3389/fnins.2021.775256/full Abstract: Top-down attention is a dynamic cognitive process that facilitates the detection of the task-relevant stimuli from our complex sensory environment. A neural mechanism capable...

Abstract With the growing popularity of touchscreen cognitive testing in rodents, it is imperative to understand the fundamental effects exposure to this paradigm can have on the animals involved. In this study, we set out to assess hippocampal-dependant learning in the APP/PS1 mouse model of Alzheimer’s...

Abstract Category learning groups stimuli according to similarity or function. This involves finding and attending to stimulus features that reliably inform category membership. Although many of the neural mechanisms under-lying categorization remain elusive, models of human category learning posit that prefrontal cortex plays a substantial role....

By Pieter M. Goltstein, Sandra Reinert, Tobias Bonhoeffer and Mark Hübener Abstract Associative memories are stored in distributed networks extending across multiple brain regions. However, it is unclear to what extent sensory cortical areas are part of these networks. Using a paradigm for visual category learning in...

Decisional anhedonia changes during learning in 5-HTT-/- compared with 5-HTT+/+ rats. This change may explain the inconsistent findings on the relationship between depression and the 5-HTT gene. Abstract Serotonin transporter gene variance has long been considered an essential factor contributing to depression. However, meta-analyses yielded inconsistent findings recently,...

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