Publications

Decisional anhedonia changes during learning in 5-HTT-/- compared with 5-HTT+/+ rats. This change may explain the inconsistent findings on the relationship between depression and the 5-HTT gene. Abstract Serotonin transporter gene variance has long been considered an essential factor contributing to depression. However, meta-analyses yielded inconsistent findings recently,...

Abstract Despite considerable advances in both in silico and in vitro approaches, in vivo studies that involve animal model systems remain necessary in many research disciplines. Neuroscience is one such area, with studies often requiring access to a complete nervous system capable of dynamically selecting between...

ABSTRACT Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions...

PUBLISHED JOURNAL ARTICLE: Genes, Brain, and Behavior - https://doi.org/10.1111/gbb.12755. ABSTRACT: While there is a strong focus on the negative consequences of maternal immune activation (MIA) on developing brains, very little attention is directed towards potential advantages of early life challenges. In this study we utilized a...

https://link.springer.com/article/10.1007/s10072-020-04910-8 Rationale The activation of the glucagon-like peptide-1 receptor (GLP-1R) has been purported to have antidepressant-like and cognitive-enhancing effects. Many people suffering from major depressive disorder (MDD) also experience deficits in cognition. While currently approved antidepressant pharmacotherapies can alleviate the mood symptoms in some patients, they do...

Kevin J. Norman Hiroyuki Koike Sarah E. McCraney Yury Garkun Julia Bateh Elisa N. Falk Susanna Im Keaven Caro Michael P. Demars Hirofumi Morishita Neuropsychopharmacology Reports, 06 May 2021 https://doi.org/10.1002/npr2.12176 https://onlinelibrary.wiley.com/doi/full/10.1002/npr2.12176 Abstract Aim: Attention is a goal‐directed cognitive process that facilitates the detection of task‐relevant sensory stimuli from dynamic...

Translating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are...

Abstract Cognitive impairment is a common and disruptive outcome for stroke survivors, which is recognized to be notoriously difficult to treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function and limits secondary neuronal loss in the thalamus after experimental stroke. There is...

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