Abstract In the striatum, cholinergic interneurons (CINs) have the ability to release both acetylcholine and glutamate, due to the expression of the vesicular acetylcholine transporter (VAChT) and the vesicular glutamate transporter 3 (VGLUT3). However, the relationship these neurotransmitters have in the regulation of behavior is not...
Abstract Sequential and cue-directed response learning in rodents have been previously shown to depend on intact striatal signaling. In particular, these behaviors rely on striatal dopamine and acetylcholine release, with an impairment of sequential response learning evident in animal models with alterations in the two systems....
Abstract Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit formation is modulated by striatal cholinergic interneurons. These interneurons express...
Authors: Ornela Kljakic1,3, Helena Janickova3, Miguel Skirzewski Prieto3, Monica S. Guzman1,3, Sara Memar3, Salah E. Mestikaway4, Yulong Li5, Timothy J. Bussey2,3, Lisa M. Saksida2,3, Marco A.M. Prado1,2,3 and Vania F. Prado1,2,3 1. Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western...