15 Oct Revealing a compulsive phenotype in cholinergic M4-/- mice depends on the T inter-trial interval initiation settings in a five choice serial reaction time task
Abstract Background: Muscarinic acetylcholine receptor 4 (M4) modulates dopaminergic neurotransmission and is a target for novel treatments of schizophrenia, cognitive deficits, and addiction. Impulsive and compulsive behaviors are key traits of addiction, yet the importance of M4 receptor signaling to these traits is poorly under- stood....