Cognitive judgement bias (CJB) refers to the interpretation of ambiguous stimuli in a negative (pessimistic) or positive (optimistic) way. Negative CJB is observed in depression and anxiety, conditions that burden affected individuals and their caregivers. Pre-clinical animal research is key to understanding CJB and developing...
Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have been generated with compound mutations, but how these affect high-level cognitive function is still not fully...
Abstract Unlocking the neural regulation of complex behavior is a foundational goal of brain science. Touchscreen-based assessments of behavior have been used extensively in the pursuit of this goal, with traditional pharmacological and neurochemical approaches being employed to provide key insights into underlying neural systems. So...
The Neuroinformatics Software Engineer will support the expansion of the open access component of our platform (Mouse Translational Research Accelerator Platform, or MouseTRAP) known as MouseBytes. The role will work collaboratively with multiple members of MouseTRAP, including the Neuroinformatics Data Scientist to integrate ABETII software...
Abstract Concerns about poor animal to human translation have come increasingly to the fore, in particular with regards to cognitive improvements in rodent models, which have failed to translate to meaningful clinical benefit in humans. This problem has been widely acknowledged, most recently in the field...