Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive assessments in detecting the impact of α-synuclein pathology in a mouse model of synucleinopathy on the...
Previous studies have implicated the α7 nicotinic acetylcholine receptor (α7nAChR) in cardioprotection via its anti-inflammatory effects, yet the underlying mechanisms remain poorly understood. Here, we investigated the impact of α7nAChR deficiency on cardiac injury induced by a 7-day isoproterenol (ISO) treatment in littermate wild-type (WT)...
Background Alzheimer's disease (AD) is the leading cause of dementia. AD disproportionately affects APOE4 carriers, who experience accelerated amyloid β (Aβ) accumulation, including cerebral amyloid angiopathy (CAA). While monoclonal antibodies (mAbs) like lecanemab reduce amyloid plaques, their use is complicated by amyloid‐related imaging abnormalities (ARIA‐likely related...
Abstract Anticipating future outcomes is a fundamental task of the brain. This process requires learning the states of the world as well as the transitional relationships between those states. In rodents, the hippocampal spatial cognitive map is thought to be one such internal model. However, evidence...