Title: Standard Operating Procedure – Progressive Ratio (PR) and Post-PR Extinction Learning (Post-PR EXT)
Author: MouseTRAP Team
Date: 01/15/2020
Version: 1
Abstract: The progressive ratio (PR) test has been designed to measure the effort a rodent is willing to expend to receive a single reward, or motivation. Previous use of this test on touchscreens in both rodents and humans have been shown to be sensitive to differences in dopaminergic activity, suggesting excellent translational validity of this test for measuring motivation in rodents. The test is performed in specially designed touchscreen based automated chambers, where a stimulus is repeatedly presented in a centre window with each trial. Mice are required to repeatedly respond to the stimulus until the ratio requirement is achieved, after which a reward is delivered. PR schedules require an increased number of responses be made with each trial following a linear ramp (e.g., +4 responses on every subsequent trial), thereby increasing the amount of effort required for a single reward with every trial. An extinction learning paradigm can also be run to assess changes in responses to reward withdrawal and related neural functioning (e.g., executive function).
DOI: 10.58064/ba2r-5a59
Link to Full SOP: mPR-v1
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