Title: Standard Operating Procedure – Paired-Associate Learning (PAL)
Author: MouseTRAP Team
Date: 11/28/2023
Version: 2
Abstract: In humans, the visual-spatial PAL task has been used to establish the early onset of cognitive impairment due to Alzheimer’s disease. The test is performed in mice with specially designed touchscreen-based automated chambers with 3 response locations (left, right and centre windows) and 3 distinct images using food reinforcers to maintain performance. Each image is assigned a unique correct location (and 2 incorrect locations). The PAL task requires the subject to learn to associate a food reward with a nose-poke response when an image appears in its correct location.
DOI: 10.58064/xqtm-yw05
Link to Full SOP: mPAL-v2
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