Abstract Cognitive impairment is a common and disruptive outcome for stroke survivors, which is recognized to be notoriously difficult to treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function and limits secondary neuronal loss in the thalamus after experimental stroke. There is...
Abstract There is emerging evidence suggesting that a cortical stroke can cause delayed and remote hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to investigate motor and cognitive outcomes after experimental stroke, and their association with secondary neurodegenerative processes. Specifically, we used a...
Falk EN, Norman KJ, Garkun Y, Demars MP, Im S, Taccheri G, Short J, Caro K, McCraney SE, Cho C, Smith MR, Lin HM, Koike H, Bateh J, Maccario P, Waltrip L, Janis M, Morishita H. Science Advances 2021 Mar 5;7(10):eabe1527. doi: 10.1126/sciadv.abe1527. https://advances.sciencemag.org/content/7/10/eabe1527 Abstract: Cognitive function depends on...
Nabel E, Garkun Y, Koike H, Sadahiro M, Liang A, Norman KJ, Taccheri G, Demars M, Im S, Caro K, Lopez S, Bateh J, Hof PR, Clem E, Morishita H Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice. Nature Communications...
Norman KJ, Riceberg JS, Koike H, Bateh, J., Lopez S, Caro, K., Kato D, Liang A, Yamamuro, K., Flanigan M, Nabel E, Brady, D., Cho, C., Riceberg, J., Sadahiro, M., Yoshitake K, Maccario P, Demars M, Waltrip L, Varga A, Russo SJ, Baxter MG, Shapiro,...
Koike, H., Demars, M.P., Short, J.A., Nabel, E.M., Akbarian, S., Baxter, M.G, Morishita, H. Neuropsychopharmacology 2016. Mar, 41 (4) 1014-23, doi: 10.1038/npp.2015.229. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748426/ Abstract: Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC)...
Choi et al. Mol Brain (2021) 14:1 https://doi.org/10.1186/s13041-020-00716-z Abstract CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. To assess the cognitive ability in CTCF cKO mice of over 20...
Note: this article currently appears as a preprint on bioRxiv and we plan to update it with some more content soon: https://www.biorxiv.org/content/10.1101/2021.02.15.431275v1.full.pdf Abstract While there is a strong focus on the negative consequences of maternal immune activation (MIA) on the developing brain, very little attention is directed...
Abstract Substance use disorders are a debilitating neuropsychiatric condition, however it remains unclear why some individuals are at greater risk of substance use disorders than others and what genetic factors determine such individual differences. Impulsivity appears a promising candidate endophenotype to bridge the gap between genetic...
Abstract Altered interactions between endocannabinoid and glutamate signaling may be involved in the pathophysiology of schizophrenia and acute psychosis. As cognitive disturbances are involved in schizophrenia, increased understanding of the roles of these neurotransmitter systems in cognition may lead to the development of novel therapeutics for...