1st International Touchscreen Symposium:
New frontiers in cognitive testing using touchscreen technology
June 5 – 6
Western University
Speakers
Jacqueline Crawley
(MIND Institute, Department of Psychiatry and Behavioral Sciences,
University of California Davis, USA)
Research Papers
Annu Rev Anim Biosci. 2017 Feb 8;5:371-389. doi: 10.1146/annurev-animal-022516-022754.
Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders.
Sukoff Rizzo SJ1, Crawley JN2.
Mol Psychiatry. 2018 May;23(5):1233-1243. doi: 10.1038/mp.2017.22. Epub 2017 Mar 21.
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
Yan L1, Shamir A1, Skirzewski M1, Leiva-Salcedo E1, Kwon OB1, Karavanova I1, Paredes D1, Malkesman O2, Bailey KR3, Vullhorst D1, Crawley JN3, Buonanno A1.
Cereb Cortex. 2015 May;25(5):1133-42. doi: 10.1093/cercor/bht293. Epub 2013 Nov 28.
Cognitive abilities on transitive inference using a novel touchscreen technology for mice.
Silverman JL1, Gastrell PT2, Karras MN2, Solomon M3, Crawley JN1.
Andrew Holmes
(Chief Laboratory of Behavioral and Genomic Neuroscience,
National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
Research Papers
Cell Rep. 2018 May 22;23(8):2264-2272. doi: 10.1016/j.celrep.2018.04.081.
Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning.
Bergstrom HC1, Lipkin AM2, Lieberman AG2, Pinard CR2, Gunduz-Cinar O2, Brockway ET2, Taylor WW2, Nonaka M2, Bukalo O2, Wills TA3, Rubio FJ4, Li X4, Pickens CL2, Winder DG5, Holmes A2.
Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14783-8. doi: 10.1073/pnas.1308198110. Epub 2013 Aug 19.
Chronic alcohol produces neuroadaptations to prime dorsal striatal learning.
DePoy L, Daut R, Brigman JL, MacPherson K, Crowley N, Gunduz-Cinar O, Pickens CL, Cinar R, Saksida LM, Kunos G, Lovinger DM, Bussey TJ, Camp MC, Holmes A.
Nat Neurosci. 2011 Nov 6;14(12):1507-9. doi: 10.1038/nn.2954.
Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF.
Graybeal C, Feyder M, Schulman E, Saksida LM, Bussey TJ, Brigman JL, Holmes A.
K. Kaang
(Department of Brain and Cognitive Sciences, Department of Biological Sciences,
College of Natural Sciences, South Korea)
http://biosci.snu.ac.kr/en/people/faculty?mode=view&profidx=1
Research Papers
J Neurosci. 2016 Aug 17;36(33):8641-52. doi: 10.1523/JNEUROSCI.0630-16.2016.
The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory.
Sim SE1, Lim CS2, Kim JI2, Seo D3, Chun H2, Yu NK2, Lee J2, Kang SJ1, Ko HG2, Choi JH2, Kim T2, Jang EH1, Han J2, Bak MS4, Park JE3, Jang DJ5, Baek D6, Lee YS7, Kaang BK8.
Behav Brain Res. 2016 Mar 15;301:63-71. doi: 10.1016/j.bbr.2015.12.016. Epub 2015 Dec 14.
Assessments of cognitive abilities in a mouse model of Parkinson’s disease with a touch screen test.
Science. 2015 Oct 2;350(6256):82-7. doi: 10.1126/science.aac7368.
Multiple repressive mechanisms in the hippocampus during memory formation.
Cho J1, Yu NK2, Choi JH2, Sim SE2, Kang SJ2, Kwak C2, Lee SW2, Kim JI2, Choi DI2, Kim VN3, Kaang BK4.
Emma Burrows
(Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre,
University of Melbourne, Australia)
www.florey.edu.au/science-research/scientist-directory/dr-emma-burrows
Research Papers
Neuropharmacology. 2017 May 1;117:219-226. doi: 10.1016/j.neuropharm.2017.02.009. Epub 2017 Feb 11.
Environmental enrichment enhances cognitive flexibility in C57BL/6 mice on a touchscreenreversal learning task.
Zeleznikow-Johnston A1, Burrows EL1, Renoir T1, Hannan AJ2.
Neuropsychopharmacology. 2015 Jul;40(8):1947-56. doi: 10.1038/npp.2015.44. Epub 2015 Feb 10.
Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5.
Burrows EL1, McOmish CE2, Buret LS3, Van den Buuse M3, Hannan AJ4.
J Mol Neurosci. 2016 Nov;60(3):371-382. Epub 2016 Sep 16.
Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer’s Disease and Dementia.
Shepherd A1, Tyebji S1, Hannan AJ1,2, Burrows EL3.
Jess Nithianantharajah
(Florey Institute of Neuroscience and Mental Health,
University of Melbourne, Australia)
https://www.florey.edu.au/science-research/scientist-directory/dr-jess-nithianantharajah
Research Papers
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt B):424-439. doi: 10.1016/j.pnpbp.2017.12.001. Epub 2017 Dec 5.
Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations.
Luo J1, Norris RH1, Gordon SL1, Nithianantharajah J2.
Sci Rep. 2015 Oct 1;5:14613. doi: 10.1038/srep14613.
Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.
Nithianantharajah J1,2, McKechanie AG3,4, Stewart TJ4, Johnstone M4, Blackwood DH4, St Clair D5, Grant SG1,2, Bussey TJ6, Saksida LM6.
Nat Neurosci. 2013 Jan;16(1):16-24. doi: 10.1038/nn.3276. Epub 2012 Dec 2.
Synaptic scaffold evolution generated components of vertebrate cognitive complexity.
Nithianantharajah J1, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, GrantSG.
Research Papers
Front Behav Neurosci. 2018 Oct 2;12:226. doi: 10.3389/fnbeh.2018.00226. eCollection 2018.
Impaired Performance of the Q175 Mouse Model of Huntington’s Disease in the Touch Screen Paired Associates Learning Task.
Piiponniemi TO, Parkkari T, Heikkinen T, Puoliväli J, Park LC, Cachope R, Kopanitsa MV.
Nat Neurosci. 2013 Jan;16(1):25-32. doi: 10.1038/nn.3277. Epub 2012 Dec 2.
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.
Ryan TJ, Kopanitsa MV, Indersmitten T, Nithianantharajah J, Afinowi NO, Pettit C, Stanford LE, Sprengel R, Saksida LM, Bussey TJ, O’Dell TJ, Grant SG, Komiyama NH. Nat Neurosci. 2013 Jan;16(1):25-32. doi: 10.1038/nn.3277. Epub 2012 Dec 2.
Neurosci Lett. 22;650:126-133. doi: 10.1016/j.neulet.2017.04.049. Epub 2017 Apr 26
Acquisition and reversal of visual discrimination learning in APPSwDI/Nos2-/- (CVN) mice.
Piiponniemi TO, Bragge T, Vauhkonen EE, Vartiainen P, Puoliväli JT, Sweeney PJ, Kopanitsa MV.
Mark Brandon
(Douglas Hospital Research Centre, Department of Psychiatry,
McGill University, Canada)
Research Papers
Curr Biol. 2018 Apr 23;28(8):1179-1188.e3. doi: 10.1016/j.cub.2018.02.061. Epub 2018 Apr 5.
Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies.
Zutshi I1, Brandon MP2, Fu ML1, Donegan ML1, Leutgeb JK1, Leutgeb S3.
Neuron. 2014 May 21;82(4):789-96. doi: 10.1016/j.neuron.2014.04.013.
New and distinct hippocampal place codes are generated in a new environment during septal inactivation.
Brandon MP1, Koenig J1, Leutgeb JK1, Leutgeb S2.
Nat Neurosci. 2013 Jun;16(6):739-48. doi: 10.1038/nn.3383. Epub 2013 Apr 21.
Segregation of cortical head direction cell assemblies on alternating θ cycles.
Research Papers
Cereb Cortex. 2016 Oct;26(10):3991-4003. doi: 10.1093/cercor/bhw229. Epub 2016 Aug 9.
Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.
Nilsson SR1, Fejgin K2, Gastambide F3, Vogt MA4, Kent BA5, Nielsen V2, Nielsen J2, Gass P4, Robbins TW5, Saksida LM5, Stensbøl TB2, Tricklebank MD3, Didriksen M2, Bussey TJ5.
Cell Rep. 2013 Nov 14;5(3):759-68. doi: 10.1016/j.celrep.2013.09.027. Epub 2013 Oct 24.
BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.
Bekinschtein P1, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ.
Nat Protoc. 2013 Oct;8(10):1985-2005. doi: 10.1038/nprot.2013.123. Epub 2013 Sep 19.
The touchscreen operant platform for assessing executive function in rats and mice.
Mar AC1, Horner AE, Nilsson SR, Alsiö J, Kent BA, Kim CH, Holmes A, Saksida LM, Bussey TJ.
Research Papers
Nat Protoc. 2013 Oct;8(10):2006-21. doi: 10.1038/nprot.2013.124. Epub 2013 Sep 19.
The touchscreen operant platform for testing working memory and pattern separation in rats and mice.
Oomen CA1, Hvoslef-Eide M, Heath CJ, Mar AC, Horner AE, Bussey TJ, Saksida LM.
J Neurosci. 2011 Mar 2;31(9):3500-7. doi: 10.1523/JNEUROSCI.5242-10.2011.
Impaired attention in the 3xTgAD mouse model of Alzheimer’s disease: rescue by donepezil (Aricept).
Romberg C1, Mattson MP, Mughal MR, Bussey TJ, Saksida LM.
Mol Brain. 2017 Jul 17;10(1):31. doi: 10.1186/s13041-017-0312-0.
Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens.
Kim EW1, Phillips BU2, Heath CJ3, Cho SY1, Kim H1, Sreedharan J4,5, Song HT6, Lee JE7, Bussey TJ2,8, Kim CH9, Kim E10,11, Saksida LM2,8.
Research Papers
Neuroscience. 2017 Mar 14;345:130-141. doi: 10.1016/j.neuroscience.2016.09.013. Epub 2016 Sep 15.
Cholinergic circuits in cognitive flexibility.
Prado VF1, Janickova H2, Al-Onaizi MA3, Prado MA1.
Cereb Cortex. 2017 Feb 1;27(2):1615-1628. doi: 10.1093/cercor/bhv349.
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone.
Al-Onaizi MA1,2, Parfitt GM1,3, Kolisnyk B1,4, Law CS5, Guzman MS1,6, Barros DM3, Leung LS5, Prado MA1,2,4,6, Prado VF1,2,4,6.
J Neurosci. 2013 Sep 11;33(37):14908-20. doi: 10.1523/JNEUROSCI.1933-13.2013.
Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex.
Kolisnyk B1, Al-Onaizi MA, Hirata PH, Guzman MS, Nikolova S, Barbash S, Soreq H, Bartha R, Prado MA, Prado VF.
Marco Prado
(The University of Western Ontario, Canada)
Research Papers
J Neurosci. 2013 Jun 19;33(25):10427-38. doi: 10.1523/JNEUROSCI.0395-13.2013.
ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains.
Dis Model Mech. 2015 Nov;8(11):1457-66. doi: 10.1242/dmm.022525. Epub 2015 Sep 17.
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Beraldo FH1, Thomas A2, Kolisnyk B3, Hirata PH2, De Jaeger X2, Martyn AC2, Fan J2, Goncalves DF2, Cowan MF2, Masood T3, Martins VR4, Gros R5, Prado VF6, Prado MA6.
Dis Model Mech. 2015 Nov;8(11):1457-66. doi: 10.1242/dmm.022525. Epub 2015 Sep 17.
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Beraldo FH1, Thomas A2, Kolisnyk B3, Hirata PH2, De Jaeger X2, Martyn AC2, Fan J2, Goncalves DF2, Cowan MF2, Masood T3, Martins VR4, Gros R5, Prado VF6, Prado MA6.
Br J Pharmacol. 2015 Oct;172(20):4919-31. doi: 10.1111/bph.13260. Epub 2015 Sep 22.
α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation.
Kolisnyk B1,2, Al-Onaizi MA1,3, Prado VF1,2,4,3, Prado MA1,2,4,3.
Flavio Beraldo
(The University of Western Ontario, Canada)
Research Papers
Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.
Beraldo FH1, Ostapchenko VG1, Caetano FA2, Guimaraes AL3, Ferretti GD4, Daude N5, Bertram L6, Nogueira KO7, Silva JL8, Westaway D5, Cashman NR6, Martins VR9, Prado VF10, Prado MA11.
Dis Model Mech. 2015 Nov;8(11):1457-66. doi: 10.1242/dmm.022525. Epub 2015 Sep 17.
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Beraldo FH1, Thomas A2, Kolisnyk B3, Hirata PH2, De Jaeger X2, Martyn AC2, Fan J2, Goncalves DF2, Cowan MF2, Masood T3, Martins VR4, Gros R5, Prado VF6, Prado MA6.
FASEB J. 2013 Sep;27(9):3594-607. doi: 10.1096/fj.13-232280. Epub 2013 May 31.
Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.
Beraldo FH1, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffé M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA.