25 Jun Cognitive deficits and altered cholinergic innervation in young adult mice carrying a Parkinson’s disease mutation
ABSTRACTImpaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson's disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The G2019S mutation in the kinase domain of leucine-rich repeat kinase 2 (LRRK2) greatly increases risk...